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A STUDY ON THE CHANGE OF SALIVARY FLUORIDE CONCENTRATION WITH TIME AFTER VARIOUS TOPICAL FLUORIDE TREATMENTS

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Abstract

±¸°­³»ÀÇ ºÒ¼Ò³óµµ¸¦ Áõ°¡½ÃÅ°´Â ¿©·¯ ¹æ¹ý¿¡´Â ºÒÈ­µÈ »ó¼öµµ¸¦ ¼·ÃëÇϰųª ºÒ¼Òº¸Á¶Á¦¸¦ º¹¿ëÇÏ´Â Àü½ÅÀû Åõ¿©¹æ¹ý°ú ºÒ¼ÒÄ¡¾à, ºÒ¼Ò¾çÄ¡¾×, ºÒ¼ÒÁ©ÀÇ µµÆ÷¿Í °°Àº ±¹¼ÒÀû Åõ¿©¹æ¹ýÀÌ ÀÖ´Ù. ±×µ¿¾È ´Ù¾çÇÑ delivery systemÀ» ÅëÇÑ ±¹¼ÒµµÆ÷¿ë ºÒ¼ÒÁ¦Á¦°¡ ÀÓ»óÀûÀ¸·Î ¿ì½ÄÁõÀ» ¿¹¹æÇϴµ¥ µµ¿òÀÌ µÈ´Ù´Â »ç½ÇÀÌ È®ÀεǾú´Ù.
ÃÖ±ÙÀÇ ¿¬±¸¿¡¼­ ºÒ¼ÒÀÇ Ç׿ì½ÄÈ¿°ú´Â Ä¡¾ÆÁÖÀ§ÀÇ oral fluid environment¼Ó¿¡¼­ ºÒ¼ÒÀÇ Á߿伺À» ÁöÀûÇÏ°í ÀÖ´Ù. ºñÀڱؼº ÀüŸ¾×³» ºÒ¼Ò³óµµ´Â ÁÖ¾îÁø ½Ã°£µ¿¾È Ä¡¸é°ú »óÈ£ÀÛ¿ëÀÌ °¡´ÉÇÑ aqueous PhaseÀÇ ºÒ¼Ò¸¦ ³ªÅ¸³½´Ù°í ÇÑ´Ù. µû¶ó¼­ Ÿ¾×³»ÀÇ ºÒ¼Ò ³óµµ¸¦ Á¶»çÇÔÀ¸·Î½á °£Á¢ÀûÀ¸·Î ¿ì½Ä¿¹¹æÈ¿°ú¿¡ ´ëÇÑ Á¤º¸¸¦ ¾òÀ» ¼ö ÀÖ´Ù.
¿ì½ÄÁõ¿¹¹æÀ» À§ÇØ È¯ÀÚ¿¡°Ô ¿©·¯ °¡Áö ±¹¼ÒµµÆ÷¹æ¹ý Áß ÇÑ °¡Áö¸¦ ÃßõÇϱ⿡ ¾Õ¼­ ÀÌµé °¢ ¹æ¹ýÀÌ Å¸¾×³» ºÒ¼Ò³óµµ¸¦ Áõ°¡½ÃÅ°´Âµ¥ ¾ó¸¶³ª È¿°úÀûÀÎÁö ¾Ë ÇÊ¿ä°¡ ÀÖ´Ù. ÀÌ¿¡ ÀúÀÚ´Â ±¹¼ÒÀû ºÒ¼ÒµµÆ÷ÈÄ ±¸°­³» ºÒ¼ÒÀÇ ÀÜ·ù·®°ú ½Ã°£º° ³óµµ¸¦ ºñ±³ÇÏ°íÀÚ ÇöÀç ±¹³»¿¡¼­ ¸¹ÀÌ ¾²ÀÌ°í ÀÖ´Â ¼­·Î´Ù¸¥ ³×°¡Áö ºÒ¼ÒÁ¦Á¦¸¦ »ç¿ëÇÏ°í ³­ µÚ ½Ã°£º¯È­¿¡ µû¸¥ Ÿ¾×³» ºÒ¼Ò³óµµ¸¦ HMDS¸¦ ÀÌ¿ëÇÑ È®»ê¹ý°ú ºÒ¼ÒÀÌ¿ÂÀü±ØÀ» »ç¿ëÇÏ¿© ÃøÁ¤ÇÏ°í ´ÙÀ½°ú °°Àº °á°ú¸¦ ¾ò¾ú´Ù.
1. ºñÀڱؼº È¥ÇÕŸ¾×³» Æò±Õ ºÒ¼Ò³óµµ´Â 0.0152ppm¡¾0.0091ppmÀ̾úÀ¸¸ç, ºñÀڱؼº Ÿ¾×ºÐºñÀ²Àº 0.34-0.36m1/minÀ¸·Î °¢±º°£¿¡ Åë°èÀû À¯ÀÇÂ÷´Â ¾ø¾ú´Ù.
2. ºÒ¼ÒÁ¦Á¦ »ç¿ëÁ÷Èĸ¦ Á¦¿ÜÇÏ°í´Â ¸ðµç ±¸°£¿¡¼­ Ÿ¾×³» ºÒ¼Ò ³óµµ´Â APF gel±º>neutral gel±º>ºÒ¼Ò¾çÄ¡¾×±º>ºÒ¼ÒÄ¡¾à±ºÀÇ ¼øÀ̾ú°í, ºÒ¼Òóġ 120ºÐ °æ°úÈÄ ºÒ¼ÒÄ¡¾à±ºÀÇ Å¸¾×³» ºÒ¼Ò³óµµ°¡, 180ºÐ °æ°úÈÄ ºÒ¼Ò¾çÄ¡¾×±ºÀÇ ºÒ¼Ò³óµµ°¡ ´ëÁ¶±º°ú Åë°èÀû À¯ÀÇÂ÷¸¦ º¸ÀÌÁö ¾ÊÀº ¹Ý¸é, 6½Ã°£ °æ°úÈıîÁö APF gel±º°ú neutral gel±ºÀÇ Å¸¾×³» ºÒ¼Ò³óµµ°¡ ´ëÁ¶±º¿¡ ºñÇØ À¯ÀǼºÀÖ°Ô ³ô°Ô À¯ÁöµÇ¾ú´Ù(p<0.05).
3. ºÒ¼ÒÁ¦Á¦ »ç¿ëÁ÷ÈĺÎÅÍ 120ºÐ °æ°úÈıîÁö Ÿ¾×³» ÀÜ·ùºÒ¼Ò·®(AUCo-120min)Àº neutral gel±º>APF gel±º>ºÒ¼Ò¾çÄ¡¾×±º>ºÒ¼ÒÄ¡¾à±ºÀÇ ¼øÀ̾ú°í, neutral gel±º°ú APF gel±ºÀÌ ´ëÁ¶±º°ú ³ª¸ÓÁö µÎ ±º¿¡ ºñÇØ À¯ÀÇÇÏ°Ô ³ôÀº °ªÀ» º¸¿´´Ù(p<0.05).

Several alternatives for increasing the fluoride concentration in the mouth, such as water flu¡©oridation, ingestion of fluoride supplements, fluoride paste, fluoride mouthrinse, application of flu¡©oride gel are available. There is an impressive body of evidence that the topically deliverd fluo¡©rides are clinically effective in inhibiting the progression of dental caries.
Recent studies on the cariostatic action of fluoride have indicated the importance of fluoride in the fluid environment of the teeth. The fluoride levels in unstimulated whole saliva can be con¡©sidered indicative of F in the aqueous phase available for interaction with the tooth surface at a given time. The retention of F in the mouth after topical fluoride treatment is considered to be an important factor in the clinical efficacy of F.
The aim of this study was to determine the elevation and clearance of fluoride in whole saliv after the following topical flouride treatments using HMDS-diffusion technique and fluoride ion electrode.
The obtained results were as follow
1. Average salivary fluoride concentration in the unstimulated whole saliva was 0.0152 ppm¡¾0.0091 ppm. Unstimulated salivary flow rate was between 0.34 - 0.36m1/min and there was no statistically significant difference among the groups(p)0.05).
2. Except for the immediate time after treatment, fluoride levels followed as APF gel)neutral gel)F-rinse)F-paste. There was no statistical difference between the salivary F concentration of F¡©paste group and that of control group after 2 hours. In case of F-rinse group, after 3 hours the concentration had dropped to baseline value. But there was statistically significant difference among the F concentraion of F gel groups and that of control group (p<0_05).
3. The mean AUCo-i2omin values were followed as neutral gel)APF gel)F-rinse)F-paste, and the values of the two former groups were significantly higher than those of the two latter groups(p(0.05).

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Ÿ¾×³» ºÒ¼Ò;±¹¼ÒÀû ºÒ¼ÒµµÆ÷;Salivary fluoride;Topical fluoride treatment

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